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Where humans' and most mythborn's blood is red, more powerful Legendary beings shelter a different type of essence.
When a Godborn or a Wyrdborn reaches apotheosis, their blood becomes the golden substance known as ichor. This allows such beings' souls to be free from body limitations and access another plane of existence.
However, when a legendary being's nature becomes more and more limited in its evolution - a.k.a they are turning into titanspawns - their blood or ichor turns slowly into a black substance called Anima. When the process is complete, a turned being does not own a Soul anymore and their nature is permanently locked. This essence characterizes all titanic creatures, from turned Gods to the most basic of titanspawns created by Titan Avatars.